منابع مشابه
Cyst formation and poly-beta-hydroxybutyric acid accumulation in Azotobacter.
Stevenson, L. H. (Louisiana State University, Baton Rouge), and M. D. Socolofsky. Cyst formation and poly-beta-hydroxybutyric acid accumulation in Azotobacter. J. Bacteriol. 91:304-310. 1966.-The relationship between cyst formation and the accumulation of poly-beta-hydroxybutyric acid (PHB) in Azotobacter vinelandii (A. agilis) was investigated. After various periods of growth, the cells were h...
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-Hydroxybutyric acid (GHB) is a therapeutic drug, a drug of abuse, and an endogenous substance that binds to lowand high-affinity sites in the mammalian brain. To target the specific GHB binding sites, we have developed a I-labeled GHB analog and characterized its binding in rat brain homogenate and slices. Our data show that [I]4-hydroxy-4-[4-(2-iodobenzyloxy)phenyl]butanoate ([I]BnOPh-GHB) bi...
متن کاملGamma hydroxybutyric acid (GHB) intoxication.
Gamma hydroxybutyric acid (GHB) is a naturally occurring analog of gamma-aminobutyric acid (GABA) that has been used in research and clinical medicine for many years. In the past decade it has become very popular as a dietary supplement and recreational drug. Acute overdose leads to profound alteration of mental status and variable amounts of respiratory depression. With proper management, most...
متن کاملA tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand.
gamma-Hydroxybutyric acid (GHB) shows great promise as a treatment for sleeping disorders but is also increasingly abused. The exact mechanism of action of GHB is yet to be delineated, but it is known to interact with specific GHB binding sites or receptors, to act as a weak agonist at GABA(B) receptors, and that GHB undergoes metabolism to GABA. In drug discrimination studies, GABA(B) agonists...
متن کاملChronic gamma-hydroxybutyric-acid use followed by gamma-hydroxybutyric-acid withdrawal mimic schizophrenia: a case report
INTRODUCTION Gamma-hydroxybutyric-acid is a potentially addictive drug known for its use in "rave" parties. Users have described heightened sexual drive, sensuality and emotional warmth. Its euphoric, sedative and anxiolytic-like properties are also sought by frequent users. Abrupt gamma-hydroxybutyric-acid withdrawal can rapidly cause tremor, autonomic dysfunction and anxiety, and may later cu...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1961
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.82.1.33-36.1961